Rabies vaccinations: are abbreviated intradermal schedules the future?
نویسندگان
چکیده
Rabies is a deadly disease, and current preexposure vaccination schedules are lengthy and expensive. We identified nine studies investigating abbreviated schedules. Although initial responses were lower, accelerated adequate immune responses were elicited after booster vaccinations. Lower-dose (and therefore cheaper) vaccination schedules may constitute a valid alternative to current vaccination schedules.
منابع مشابه
Prophylactic immunization of humans against rabies by intradermal inoculation of human diploid cell culture vaccine.
The antirabies human diploid cell vaccine produced by 1'Institute Merieux, Lyon, France, was administered intradermally to 35 high-risk volunteers using 0.2-ml amounts and various immunization schedules. Three groups never before vaccinated against rabies developed virus-neutralizing antibodies, the titer of which was dose dependent. A single injection stimulated the formation of antibodies. Fo...
متن کاملLow-cost intradermal rabies vaccination is indeed very promising.
TO THE EDITOR—We read with great interest the recent article by Wieten et al in Clinical Infectious Diseases [1] and, being involved in ongoing research strictly related to this topic, we wish to bring our contribution to their reflections. First, we fully agree that a lower-dose, abbreviated intradermal preand postexposure vaccination schedule may constitute a valid, shorter, and cheaper alter...
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Human immunodeficiency virus (HIV)-infected patients with low CD4(+) T lymphocyte counts had a poor neutralizing antibody response to pre- and postexposure rabies vaccination. This study of HIV-infected patients with CD4(+) T lymphocyte counts < 200/microL indicated that patients had a poor response after 4-site intradermal vaccinations (4-4-4-0-2-2, doubling the intradermal doses of cell-cultu...
متن کاملComparison of Immune Responses following Intradermal and Intramuscular Rabies Vaccination Methods
Rabies is a zoonotic viral disease. The causative agent is a negative-sense RNA genome virus of the genus Lyssavirus (Family: Rhabdoviridae). The disease, commonly transmitted by rabid dogs, is the cause of mortality of over 59000 humans worldwide annually. This disease can be prevented before the development of symptoms through proper vaccination even after exposure. Hence, improvement of the ...
متن کاملWHO Position Paper on Rabies vaccine. Selected references
According to official WHO data more than 2.5 billion people are at risk in over 100 countries reporting the disease. Rabies mortality ranks ten in all infectious diseases worldwide. There are still about 50,000 to 60,000 human deaths annually although effective vaccines for post-exposure treatment are available. Most affected are the tropical countries in Africa, Asia, South America, and Oceani...
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 56 3 شماره
صفحات -
تاریخ انتشار 2013